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Some states have added GLP-1 coverage for obesity while others continue to exclude weight loss medications from their formularies entirely

Cost analysis favors injection significantly - nasal spray uses 3x more peptide resulting in 2.8x higher per-dose costs ($46 vs $16) that accumulate substantially over time

Upon undertaking further investigations to determine the factors mediating these changes, the investigators found that baseline white adipose tissue IL-1beta secretion accounted for much of the association between apoB and several diabetes-related traits, and these links were lost after omega-3 supplementation

Neurosci Lett (2017) 636:12733